Piroxicam inhibits prostaglandin synthesis by decreasing the activity of enzyme cyclooxygenase , which results in decreased formation of prostaglandin precursors from arachidonic acid .

Piroxicam topical gel is used for tendinitis , post – operation or post – trauma edema , and relief of local pain and inflammation .

Pruritus ; Rash ; Hives ; Photosensitivity ; Burning feeling of skin ; Dryness , scaliness , or peeling of skin ; Contact dermatitis or hypersensitivity .

Hypersensitivity to piroxicam , any component of the formulation , aspirin or other NSAIDs .

Avoid contact with eyes and mucous membranes . Safety and efficacy in children < 12 years of age have not been established .

Concurrent use of these medications with topical piroxicam may cause a cumulative irritant effect , resulting in excessive irritation of the skin : Abrasive or medicated soaps or cleaners ; Acne preparations or preparations containing a peeling agent , such as resorcinol , salicylic acid , sulfure ; Topical alcohol – containing preparations such as after – shave lotions , astringents , perfumed toiletries , shaving creams or lotions ; Cosmetics or soaps with a strong drying effect ; Isotretinoin ; Medicated cosmetics or cover – ups .

Usual adult , adolescent and children (12 years of age and over):
It is applied to the affected site 3 to 4 times daily . Treatment should be reviewed after 14 days or after 28 days if used for osteoarthritis .

• Topical Gel 0.5% , 60 g tubes.

• USP DI, 2004
• Up To Date, Vol. 13.3 (2005)
• Martindale, The Complete Drug Reference, 34 rd edition 2005