Category : GASTROINTESTINAL

Name : PANTOPRAZOLE (PANTOKIM®)     Type & Dosage : E.C. Tab. ; 20 mg Package : 30

Pharmacologic Category Gastric acid pump inhibitor ; Antiulcer agent . Mechanism Of Action Pantoprazole suppresses gastric acid secretion by specific inhibition of hydrogen – potassium – ATP – ase enzyme system found at the secretory surface of parietal cells . Indications Prophylaxis and treatment of gastroesophageal reflux disease , Erosive esophagitis , Duodenal and gastric ulcer , Gastric hypersecretory disorders associated with Zollinger – Ellison syndrome , As adjunct treatment of Helicobacter pylori – associated duodenal ulcer . Side Adverse Effects Anaphylaxis , Erythema multiform , Hyperglycemia , Jaundice , Optic neuropathy , Pancreatitis , Diarrhea , Headache , Abdominal pain , Anxiety , Arthralgia , Back pain , Bronchitis , Urinary tract infection , Flatulence , Constipation , Dyspepsia , Dizziness , Pharyngitis , Rhinitis , Sinusitis , Skin rash , Itching . Contraindications Hypersensitivity to pantoprazole , substituted benzimidazoles or any component of formulation . Pregnancy FDA Pregnancy Category B . Breast Feeding Use only if clearly needed . Drug Interactions Pantoprazole , by increasing gastric pH , may interfere with the absorption of ampicillin , iron salts , ketoconzole and itraconzole . Pantoprazole may increase the effects of amiodarone , fluoxetine , phenytion , pioglitazone , rosiglitazone , sertraline and warfarin . Dietary Considerations It is best if taken before breakfast . Administration And Dosage Gastroesophageal reflux disease ( treatment ) – Oral , 40 mg per day for up to 8 weeks ; Gastroesophageal reflux disease ( prophylaxis ) – Oral , 20 mg once a day ; H. pylori – associated duodenal ulcer ( treatment ) – Oral , triple therapy regimens of pantoprazole 40 mg , plus clarithromycin 500 mg , plus either amoxicillin 1000 mg or metronidazole 500 mg , in which all three medications are taken two times a day for 7 days ; Duodenal ulcer ( treatment ) – Oral , 40 mg per day for up to 2 weeks ; Gastric ulcer ( treatment ) – Oral , 40 mg per day for up to 4 weeks . How Supplied Tablet , 20 mg . References - USP DI , 2005 , - Up To Date , 2005 , - Martindale , The Complete Drug Reference , 34th edition , 2005