Category : VITAMINES, NUTRITIONAL AGENTS

Name : VITAMIN B1     Type & Dosage : SCORED Tab. ; 300 mg Package : 30

Pharmacologic Category Vitamin (water – soluble ); Nutritional supplement Mechanism Of Action Vitamin B1 (thiamine) combines with ATP to form a coenzyme , thiamine pyrophosphate ( thiamine diphosphate , cocarboxylase) , which is necessary for carbohydrate metabolism. Indications Prevention and treatment of thiamine deficiency states. Deficiency of thiamine may lead to beriberi (dry or wet ) or Wernicke’s encephalopathy . Requirements may be increased and /or supplementation may be necessary in the following persons or conditions : burns , chronic fever , gastrectomy , chronic hemodialysis , hepatic – biliary tract disease (alcoholism with cirrhosis , hepatic function impairment) , hyperthyroidism , prolonged infection , intestinal disease (celiac , ileal resection , topical sprue , regional enteritis) , persistent diarrhea , heavy manual labor for long periods of time , prolonged stress , patients receiving TPN or undergoing rapid weight loss or in those with malnutrition , pregnancy , breast – feeding period , treatment of subacute necrotizing encephalomyelopathy , treatment of maple syrup urine disease , treatment of pyruvate carboxylase deficiency , treatment of hyperalaninemia. Side Adverse Effects Incidence rare – Anaphylactic reaction including coughing , difficulty in swallowing , hives , itching , swelling of face , lips , or eyelids , wheezing or difficulty in breathing , cardiovascular collaps ( usually after a large IV dose) ; paresthesia. Contraindications Hypersensitivity to thiamine or any component of the formulation Warnings Precautions IV glucose loading may precipitate or worsen wernicke’s encephalopathy in thiamine –deficient patients ; thiamine should be administered prior to glucose. Pregnancy FDA pregnancy category A. Problems in humans have not been documented with intake of normal daily recommended amounts. Breast Feeding Thiamine enters breast milk . Problems have not been documented with intake of normal daily recommended amounts. Drug Interactions Neuromuscular blocking agents Dietary Considerations High carbohydrate diets may increase thiamine requirement. Administration And Dosage Usual adult and adolescent dose: Deficiency (prophylaxis) – Oral , amount based on normal daily recommended intakes : Persons mg Adolescent and adult males 1.2 - 1.5 Adolescent and adult females 1- 1.1 Pregnant females 1.5 Breast – feeding females 1.6 Deficiency (treatment ) – Treatment dose is individualized by prescriber based on severity of deficiency . The following dosage has been established : Beriberi (initial in mild or maintenance following severe) –Oral , 5 to 10 mg three times a day. Genetic enzyme deficiency diseases – Oral , 10 to 20 mg per day as a single dose (dosage of up to 4 grams per day in divided doses has been used) . Usual pediatric dose: Deficiency (prophylxis) – Oral , amount based on intake of normal daily recommended intakes : Persons mg Birth to 3 years of age 0.3 - .0.7 4 to 6 years of age 0.9 7 to 10 years of age 1 Deficiency (treatment) – Treatment dose is individualized by prescriber based on severity of deficiency . The following dosage has been established : Beriberi(mild) – Oral , 10 mg per day. How Supplied Tablet 300 mg thiamine hydrochloride Storage Store below 30°C. Protect from light and moisture. References USP DI, 2004 Up To Date, Vol. 13.1 (2005) Martindale, The Complete Drug Reference, 33 rd edition 2002